Dr. Federico Montechiaro from Ugo Basile SRL

Current behavioral tests that measure temperature, hypersensitivity/hyperalgesia, etc. produce conflicting results (especially if in the cold range, e.g. for cold allodynia studies).

This is likely due to a number of factors, including previous device design and the consequent insufficient test sensitivity and repeatability.

The inventor of the TGR (Thermal Gradient Ring) method, Dr. Zimmermann, from the University of Erlangen in Germany and Ugo Basile were able to improve these aspects.

The goal was to provide the scientific community with an automated device that improves not only result quality but also makes the experiment fully automated, easy to perform and high-throughput. 

To achieve this, a circular arena, which provides the adjustable thermal gradient and measures the position, the time spent, etc. by mice at different adjustable temperatures.

This approach is especially useful when studying «cold receptors», as shown by Touska et al. (2016) and, in general, it is essential when the differences between the treatment groups or animal phenotypes do require the best accuracy and sensitivity to achieve statistically significant findings in the temperature sensitivity and pain field.

Markus Uhrig & Andreas Friese. OLS - OMNI Life Science GmbH & Co. KG

Here, we present a workflow that is centered around your cell culture experiments. This workflow is designed in such a way that it creates a low-stress environment for your cells and the people who are performing the experiments. We introduce devices for 2-dimensional and 3-dimensional cell culture experiments with a special focus on quality control, real-time monitoring and automated data collection to expedite the submission process for publication. The quality control comprises the screening for mycoplasma, cell counting and cryopreservation. Real-time monitoring of cells often results in a more valuable read-out than end point assays. Thus, we present our zenCELLowl and xCELLigence capable of automated real-time monitoring. Furthermore, we introduce to you our CERO 3D incubator and bioreactor for the 3-dimensional expansion of pluripotent stem cells, generation of spheroids, organoids and long-term cultivation of tumor tissue. 

 

Corinne Tancredi Charbonnet. Molecular Devices LLC